The production of pharmaceutical products requires highest precision. Mixer-granulators made by DIOSNA enable an excellent quality of the products. Our flexible solutions allow the execution of two work steps: mixing and granulating. DIOSNA provides single machines as well as complete lines for R&D, clinical trials and production scale.
In the pharmaceutical industry, granulation is a comprehensive process which includes expensive and detailed test procedures during the R&D phase. Independent from the size, each mixer-granulator made by DIOSNA is characterised by easy handling and cleaning. Not only mixing and wet granulating but also vacuum drying is possible. With a wide range of batch sizes and a series of available options, all granulation systems are customised to individual requirements.
for the pharmaceutical production
for laboratory sizes of 0.25 l to 6 l
for the laboratory sizes of 0.25 l to 10 l
Quick bowl change between 10 l and 80 l
for the production capacities of 100 l to 150 l
for the production scale from 300 l to 1800 l
for the laboratory sizes of 10 l to 60 l
Our range in mixing and granulating starts with the laboratory mixer-granulator of the P 1-6 series. As benchtop device, the granulator can be used in a flexible way and allows the production of dry mixtures and wet granulates in the smallest scale. The device especially designed for easy operation and cleaning is controlled via a touchscreen that can be optionally replaced by a tablet PC. The user-friendly P 1-6 series has a number of advantages based on its modular design like easy retrofitting of components, complete disassembly of the mixing units and tool-free bowl changeover.
In addition, several options are available. While the moveable base cabinet ensures increased mobility, the PAT software with an active power measurement provides optimum control over technical processes. Pumps, pressure vessels and nozzles enable perfect distribution of binders. Six different bowls from 0.25 to 6 litres guarantee highest flexibility, also in terms of batch sizes.
The laboratory processor P/VAC - 10 represents an enhancement of the P 1-6 with a range of batch sizes from 0.25 to 10 litres. The P/VAC – 10 enables changing from small to large batches or vice versa due to a rapid replacement of bowls of different sizes like the P 1-6 series. An important difference to the P 1-6 series is the optional vacuum dryer for wet granulates, whereby numerous further options can be selected. They include, for instance, an integrated peristaltic pump, explosion protection as well as different containment solutions for highly active substances.
With the pilot plant processor P/VAC 10 - 60 and the even more flexible P/VAC 10 - 80 RC, DIOSNA offers ideal systems for a flexible production of clinical batches. The P/VAC 10 - 60 comes up with changeable bowls of 10 to 60 litres. The processor enables the manufacture of dry mixtures and wet granulates. Thanks to the integrated control system, the models are mobile, score with their highly-efficient impeller and bowl design and provide optimum vacuum drying. CIP-capable air seals as well as various containment solutions underline the professionality of the granulation equipment. The P/VAC 10 - 80 RC models fit perfect if granulation shall take place within a complete granulation line. "RC" stands for "Rapid change" and emphasises the easy change of bowls. Production and technical areas are separated with motors, control units and WIP/CIP-equipment installed in the technical zone. The wide range of batch sizes from 10 to 80 litres, the optionally integrated wet mill and the optionally installed binder pump provide further advantages.
The mixer-granulators P100 and P150 are two compact machines which can be flexibly installed. The compact design, easy cleaning and efficient impeller and container design lead to perfect results. As with all DIOSNA mixer-granulators, the batch sizes range from 30 to 90% of the total volume. Optional equipment includes a pressure shock resistant version up to 12 bar, attached wet mills and various containment solutions
The mixer-granulators P300 - P1800 offer high performance without compromise. In addition to an optimal process flow, they are extremely robust and convince with an intelligent design. While the proven "Through the wall”-design enables efficient use, the machine base also serves as an operator platform which results in a small footprint. Furthermore, the system scores with automatic cleaning and optional integrated industrial PC control.
The DIOSNA granulation lines offer the combination of mixer-granulators and fluid bed processors in one system. The compact CCS 10 - 80 RC series as well as the larger CCS/CGS 150 – 1300 series operate with two HMIs that optionally allow the simultaneous or independent use of both plant components. The granulation lines are an excellent solution for containment requirements due to the completely closed product transfer. A further advantage is the small space requirement.
Each mixing and granulation system made by DIOSNA is designed for professional application and has a considerable range of functions. Although intuitive operation is one of the advantages of our systems, we recommend to attend one of our training courses. There, we introduce the participants to all aspects of granulation to exhaust the full potential of our machines and systems. Just contact us to arrange a training appointment.